How should Aspirin be administered to reduce gastrointestinal irritation?

Administering Aspirin with food and a proton pump inhibitor is the recommended approach to reduce gastrointestinal irritation. Aspirin is known to cause irritation of the gastric lining, which can lead to discomfort, ulcers, or bleeding in some patients. When taken with food, Aspirin's absorption is slowed, which can help minimize its direct contact with the gastric mucosa, reducing irritation.

The use of a proton pump inhibitor is particularly beneficial as these medications decrease stomach acid production, further protecting the stomach lining and allowing for safer use of Aspirin, especially in patients who may be at higher risk for gastrointestinal issues. This combination effectively mitigates the potential harmful effects of Aspirin on the gastrointestinal tract, making it a safer option for long-term use.

Taking Aspirin on an empty stomach can enhance its absorption but also increases the risk of gastrointestinal irritation. Using water only or pairing it with antacids does not provide the same level of protective effect for the stomach and may not adequately address the risk of irritation that Aspirin carries.