What is a common side effect associated with alpha-glucosidase inhibitors?

Alpha-glucosidase inhibitors, such as acarbose and miglitol, are used in the management of type 2 diabetes by inhibiting the enzyme that breaks down carbohydrates in the intestine. This action slows glucose absorption, which can lead to certain side effects in the gastrointestinal tract.

Flatulence is a common side effect associated with these medications because the undigested carbohydrates that reach the colon are fermented by bacteria, producing gas. This can lead to increased flatulence as the body is unable to fully absorb these carbohydrates.

Other gastrointestinal side effects may include diarrhea and abdominal pain, but flatulence is particularly notable and frequently reported by patients taking alpha-glucosidase inhibitors. Understanding this side effect is crucial for healthcare providers to manage patient expectations and provide education on what to anticipate during treatment.