What is a common side effect of biguanides related to weight?

The correct answer highlights that significant weight gain is not typically associated with biguanides, particularly metformin, which is a common representative of this class. Instead, the use of metformin is often linked to weight loss or weight neutrality.

Biguanides, such as metformin, enhance insulin sensitivity and reduce hepatic gluconeogenesis, which can lead to improved glycemic control without the associated weight gain that other diabetic medications may trigger. In fact, many patients taking metformin report weight loss or experience weight stabilization rather than increases. This is particularly beneficial for individuals with type 2 diabetes, many of whom may struggle with obesity.

Understanding the pharmacological effects of biguanides is crucial for anticipating their impact on weight, which can help guide treatment choices and patient counseling.