What is a contraindication for using ACE inhibitors?

A history of angioedema is a significant contraindication for the use of ACE inhibitors. Angioedema refers to a localized swelling, often around the eyes and lips, and sometimes the throat, which can pose serious health risks, including difficulty breathing. This condition can be a side effect of ACE inhibitors due to their mechanism of action, which affects bradykinin metabolism. In patients who have previously experienced angioedema, the risk of recurrence is elevated if they are prescribed ACE inhibitors, making this a clear contraindication.

While hypertension is often treated with ACE inhibitors, they are not contraindicated in this scenario. Pregnancy is another serious concern with ACE inhibitors, as their use during pregnancy can lead to fetal harm, particularly in the second and third trimesters, but it does not specifically relate to an individual’s prior health history as angioedema does. Renal failure is also a consideration with ACE inhibitors due to their effects on renal function; however, it is not an absolute contraindication and may be managed with careful monitoring. Thus, history of angioedema stands out as a definitive contraindication.