What is a specific risk factor for patients taking ACE inhibitors?

Angioedema is a specific risk factor associated with the use of ACE inhibitors. This condition involves the rapid swelling of the deeper layers of the skin and can occur in areas such as the face, throat, and extremities. ACE inhibitors, which are commonly prescribed for conditions like hypertension and heart failure, can lead to the accumulation of bradykinin—a peptide that promotes vasodilation and is normally degraded by ACE. When inhibited, the increased levels of bradykinin can trigger angioedema in susceptible individuals, making it a critical concern for clinicians when monitoring patients on these medications.

While the other options reflect medical concerns, they are not specific risks associated with ACE inhibitors. Increased heart rate is more closely linked to other cardiovascular issues or medications; hypoglycemia is primarily a concern for diabetic patients using insulin or certain oral hypoglycemic agents; and dehydration can occur for various reasons, such as fluid loss or certain diuretics, but is not a direct risk related to ACE inhibitor therapy. Thus, the association of angioedema with ACE inhibitors distinctly highlights the importance of awareness and monitoring for this specific adverse effect.