Which drug class is known to cause dependency and withdrawal symptoms?

Prepare for the Houston Methodist Pharmacology Exam. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready to ace your test!

Benzodiazepines are a class of medications that are widely recognized for their potential to cause physical dependence and withdrawal symptoms when they are used over an extended period or in high doses. The mechanism behind this lies in how benzodiazepines interact with the central nervous system. They enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to increased inhibition of neural activity, which can produce sedative, anxiolytic, and muscle-relaxant effects.

When individuals use benzodiazepines regularly, the body may adapt to their presence, leading to tolerance, where higher doses are required to achieve the same effects. If the medication is then reduced or stopped abruptly, withdrawal symptoms can occur. These withdrawal symptoms can range from anxiety, insomnia, and agitation to more severe manifestations like seizures.

In contrast, the other classes listed—antidepressants, beta-blockers, and antipsychotics—generally do not lead to the same level of physical dependence. While some antidepressants may cause discontinuation syndrome, it's not classified as withdrawal in the same way as benzodiazepines. Beta-blockers and antipsychotics can have other side effects and considerations, but they are less associated with dependency issues in

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