Which is a common side effect of selective serotonin reuptake inhibitors (SSRIs)?

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for the treatment of depression and anxiety disorders. One of the most commonly reported side effects associated with SSRIs is sexual dysfunction. This can manifest in various ways, including decreased libido, difficulty achieving orgasm, or erectile dysfunction.

The mechanism behind this side effect is thought to be related to the increased serotonin levels in the synaptic cleft. Elevated serotonin can inhibit the pathways that influence sexual arousal and function. Due to this significant impact on patients' quality of life, identification and management of sexual dysfunction are important considerations when prescribing SSRIs.

While SSRIs can also cause other side effects, such as weight gain and nausea, these are generally less prevalent than sexual dysfunction. Insomnia might occur as well but is typically less directly linked to the serotonergic effects compared to sexual side effects. Recognizing sexual dysfunction as a common side effect is crucial for healthcare professionals when discussing treatment options with patients.