Which medication is indicated for both depression and smoking cessation?

Bupropion is the correct choice as it is a unique medication that operates as an antidepressant and is also approved as a smoking cessation aid. Its dual action is attributed to its ability to inhibit the reuptake of norepinephrine and dopamine, which can help alleviate depressive symptoms while also reducing withdrawal symptoms and cravings associated with nicotine addiction.

This medication is particularly beneficial for individuals who experience depression and are looking to quit smoking, as it addresses both the mood disorder and the addiction. Bupropion’s effectiveness in both areas has made it a widely prescribed option for patients dealing with these co-occurring issues.

Other medications mentioned, such as mirtazapine, duloxetine, and venlafaxine, primarily focus on treating depression and do not have the same indication for smoking cessation. Therefore, bupropion stands out by being suitable for both conditions, making it the most appropriate answer.