Which two types of insulin make up premixed insulin?

Premixed insulin consists of two different types of insulin that work together to provide both a rapid-acting and an intermediate-acting effect. NPH (neutral protamine Hagedorn) is an intermediate-acting insulin that helps control blood sugar levels throughout the day, while Regular insulin is a short-acting insulin that provides a more immediate effect, especially around mealtime. The combination of these two types allows for better management of blood glucose levels by covering both basal insulin needs and postprandial glucose spikes.

In contrast, the other options involve different combinations of insulin types that do not represent the typical formulations used in premixed insulins. For instance, Lispro and Glargine are both rapid-acting and long-acting insulins respectively but are not combined in a premixed formulation. Similarly, the combinations of Regular with Lente or Detemir with Regular do not match the conventional premixed insulin profiles that are standard in clinical practice. Thus, the pairing of NPH and Regular is the correct answer for premixed insulin, as it effectively addresses both immediate and long-term insulin requirements for individuals with diabetes.